Immune correlates of tuberculosis disease and risk translate across species.

ABSTRACT: One quarter of the world's population is infected with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Although most infected individuals successfully control or clear the infection, some individuals will progress to TB disease. Immune correlates identified using animal models are not always effectively translated to human TB, thus resulting in a slow pace of translational discoveries from animal models to human TB for many platforms including vaccines, therapeutics, biomarkers, and diagnostic discovery. Therefore, it is critical to improve our poor understanding of immune correlates of disease and protection that are shared across animal TB models and human TB. In this study, we have provided an in-depth identification of the conserved and diversi

SUBMITTER: Ahmed M 

PROVIDER: S-EPMC7354419 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature