ABSTRACT: Mimetic peptides are potential therapeutic agents for atherosclerosis. d-[113,114,115,116,117,118,119,120,121,122]apolipoprotein (apo) J (D-[113,114,115,116,117,118,119,120,121,122]apoJ) is a 10-residue peptide that is predicted to form a class G* amphipathic helix 6 from apoJ; it shows anti-inflammatory and anti-atherogenic properties. In the present study, we analyzed the effect of d-[113,114,115,116,117,118,119,120,121,122]apoJ in low-density lipoprotein receptor knockout mice(LDLR-KO) on the development of atherosclerosis and lipoprotein function. Fifteen-week-old female LDLR-KO mice fed an atherogenic Western-type diet were treated for eight weeks with d-[113,114,115,116,117,118,119,120,121,122]apoJ peptide, a scrambled peptide, or vehicle. Peptides were administered subcutaneously th
