PCSK9 in African Americans and Caucasians in Relation to Lp(a) Level, Apo(a) Size and Heritability.

ABSTRACT:

Context

Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces lipoprotein(a) [Lp(a)] levels, but the association of PCSK9 with Lp(a) level and its major determinant, apolipoprotein(a) [apo(a)] size, is not fully understood.

Objective

To assess the relationship between PCSK9, Lp(a) level, apo(a) size, age, and ethnicity/race.

Design

Cross-sectional.

Setting

General population.

Participants

Healthy African Americans and Caucasians (n = 267); age range: 6 to 74 years.

Interventions

None.

Main outcome measures

PCSK9 levels, apo(a) isoform and LPA allele sizes, and isoform-specific Lp(a) levels.

Results

Plasma PCSK9 levels were significantly higher in African Americans vs Caucasians, in females vs males, and i

SUBMITTER: Enkhmaa B 

PROVIDER: S-EPMC7358566 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature