α_2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference.

ABSTRACT: The α_2a-adrenergic receptor (α_2a-AR) agonist guanfacine has been investigated as a potential treatment for substance use disorders. While decreasing stress-induced reinstatement of cocaine seeking in animal models and stress-induced craving in human studies, guanfacine has not been reported to decrease relapse rates. Although guanfacine engages α_2a-AR autoreceptors, it also activates excitatory G_i-coupled heteroreceptors in the bed nucleus of the stria terminalis (BNST), a key brain region in driving stress-induced relapse. Thus, BNST α_2a-AR heteroreceptor signaling might decrease the beneficial efficacy of guanfacine. We aimed to determine the role of α_2a-AR heteroreceptors and BNST G_i-GPCR signaling in stress-in

SUBMITTER: Perez RE 

PROVIDER: S-EPMC7360592 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature