Ontology highlight
ABSTRACT:
SUBMITTER: Mzoughi S
PROVIDER: S-EPMC7360777 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nature communications 20200714 1
PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its low expression in adult tissues and its overexpression in B-cell lymphomas. Despite its well characterized role in stem cell biology and during early development, the role of PRDM15 in cancer remains obscure. Herein, we demonstrate that while PRDM15 is ...[more]