The association of partial pressures of oxygen and carbon dioxide with neurological outcome after out-of-hospital cardiac arrest: an explorative International Cardiac Arrest Registry 2.0 study.

ABSTRACT:

Background

Exposure to extreme arterial partial pressures of oxygen (PaO₂) and carbon dioxide (PaCO₂) following the return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA) is common and may affect neurological outcome but results of previous studies are conflicting.

Methods

Exploratory study of the International Cardiac Arrest Registry (INTCAR) 2.0 database, including 2162 OHCA patients with ROSC in 22 intensive care units in North America and Europe. We tested the hypothesis that exposure to extreme PaO₂ or PaCO₂ values within 24 h after OHCA is associated with poor neurological outcome at discharge. Our primary analyses investigated the association between extreme PaO₂ and PaCO₂

SUBMITTER: Ebner F 

PROVIDER: S-EPMC7362652 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature