Lack of Association Between the CCR5-delta32 Polymorphism and Neurodegenerative Disorders.

ABSTRACT:

Objective

Recent studies have suggested that diminished Ccr5 functioning has an effect on synaptic plasticity and hippocampal memory in mouse models. CCR5-delta32, a 32-bp frameshift deletion in human CCR5 encoding a nonfunctional receptor, has been reported to have a protective effect against human immunodeficiency virus infection but its role as a modifier of neurodegenerative disease has been minimally explored. We investigated whether the CCR5-delta32 polymorphism could have an effect in the context of human neurodegenerative diseases.

Methods

We examined the frequency of the CCR5-delta32 polymorphism in a large and well-characterized cohort including 1425 patients with neurodegenerative dementias and 2032 controls.

Results

We did not observe a significant associa

SUBMITTER: Wojta KJ 

PROVIDER: S-EPMC7365743 | biostudies-literature | 2020 Jul-Sep

REPOSITORIES: biostudies-literature