Changes in cerebral oxygenation and cerebral blood flow during hemodialysis - A simultaneous near-infrared spectroscopy and positron emission tomography study.

ABSTRACT: Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO₂) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [¹⁵O]H₂O positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO₂ and CBF. In 12 patients aged ≥ 65 years, NIRS and PET were performed simultaneously: before (T1), early after start (T2), and at the end of hemodialysis (T3). Between T1 and T3, the relative change in frontal rSO₂ (ΔrSO₂) was -8 ± 9% (P = 0.001) and -5 ± 11% (P = 0.08), whereas the relative change in frontal gray matter CBF (ΔCBF

SUBMITTER: Polinder-Bos HA 

PROVIDER: S-EPMC7370620 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature