Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez Miera G
PROVIDER: S-EPMC7379557 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
González Miera Greco G Bermejo López Aitor A Martínez-Castro Elisa E Norrby Per-Ola PO Martín-Matute Belén B
Chemistry (Weinheim an der Bergstrasse, Germany) 20190123 10
1,4- and 1,5-diols undergo cyclodehydration upon treatment with cationic N-heterocyclic carbene (NHC)-Ir<sup>III</sup> complexes to give tetrahydrofurans and tetrahydropyrans, respectively. The mechanism was investigated, and a metal-hydride-driven pathway was proposed for all substrates, except for very electron-rich ones. This contrasts with the well-established classical pathways that involve nucleophilic substitution. ...[more]