Is a definitive trial of prehospital continuous positive airway pressure versus standard oxygen therapy for acute respiratory failure indicated? The ACUTE pilot randomised controlled trial.

ABSTRACT:

Objectives

To determine the feasibility of a large-scale definitive multicentre trial of prehospital continuous positive airway pressure (CPAP) in acute respiratory failure.

Design

A single-centre, open-label, individual patient randomised, controlled, external pilot trial.

Setting

A single UK Ambulance Service, between August 2017 and July 2018.

Participants

Adults with respiratory distress and peripheral oxygen saturations below British Thoracic Society target levels despite controlled oxygen treatment.

Interventions

Patients were randomised to prehospital CPAP (O-Two system) versus standard oxygen therapy in a 1:1 ratio using simple randomisation.

Primary and secondary outcome measures

Feasibility outcomes comprised recruitment rate, adherence

SUBMITTER: Fuller G 

PROVIDER: S-EPMC7380855 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature