Identification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases.
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ABSTRACT:
SUBMITTER: Saxena S
PROVIDER: S-EPMC7381621 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Identification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases.
Saxena Shrishti S Lokhande Hrishikesh H Gombolay Grace G Raheja Radhika R Rooney Timothy T Chitnis Tanuja T
Scientific reports 20200724 1
MOG-antibody associated disease (MOG-AAD) is a recently recognized demyelinating disorder predominantly affecting children but also occurs in adults, with a relapsing course in approximately 50% of patients. We evaluated peripheral blood mononuclear cells from MOG-AAD patients by flow cytometry and found a strong antigen specific central memory cell (CMC) response with increased Th1 and Th17 cells at the time of a relapse. Transcriptomic analysis of CMCs by three independent sequencing platforms ...[more]
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