Unique cysteine-enriched, D2L5 and D4L6 extracellular loops in Ca_V3 T-type channels alter the passage and block of monovalent and divalent ions.

ABSTRACT: Invertebrate LCa_V3 shares the quintessential features of vertebrate Ca_V3 T-type channels, with a low threshold of channel activation, rapid activation and inactivation kinetics and slow deactivation kinetics compared to other known Ca²⁺ channels, the Ca_V1 and Ca_V2 channels. Unlike the vertebrates though, Ca_V3 T-type channels in non-cnidarian invertebrates possess an alternative exon 12 spanning the D2L5 extracellular loop, which alters the invertebrate LCa_V3 channel into a higher Na⁺ and lower Ca²⁺ current passing channel, more resembling a classical Na_V1 Na⁺ channel. Cnidarian Ca_V3 T-type channels can possess genes with alternative cysteine-rich, D4L6 extrace

SUBMITTER: Guan W 

PROVIDER: S-EPMC7382465 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature