Age-stratified longitudinal study of Alzheimer's and vascular dementia patients.

ABSTRACT:

Introduction

Similar symptoms, comorbidities and suboptimal diagnostic tests make the distinction between different types of dementia difficult, although this is essential for improved work-up and treatment optimization.

Methods

We calculated temporal disease trajectories of earlier multi-morbidities in Alzheimer's disease (AD) dementia and vascular dementia (VaD) patients using the Danish National Patient Registry covering all hospital encounters in Denmark (1994 to 2016). Subsequently, we reduced the comorbidity space dimensionality using a non-linear technique, uniform manifold approximation and projection.

Results

We found 49,112 and 24,101 patients that were diagnosed with AD or VaD, respectively. Temporal disease trajectories showed very similar disease patterns

SUBMITTER: Jorgensen IF 

PROVIDER: S-EPMC7383608 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature