Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging.

ABSTRACT:

Introduction

We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging.

Methods

We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals.

Results

The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns.

Discussion

We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and

SUBMITTER: Machulda MM 

PROVIDER: S-EPMC7383989 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature