Ontology highlight
ABSTRACT:
SUBMITTER: Jandke A
PROVIDER: S-EPMC7387338 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nature communications 20200728 1
Butyrophilin-like (Btnl) genes are emerging as major epithelial determinants of tissue-associated γδ T cell compartments. Thus, the development of signature, murine TCRγδ<sup>+</sup> intraepithelial lymphocytes (IEL) in gut and skin depends on Btnl family members, Btnl1 and Skint1, respectively. In seeking mechanisms underlying these profound effects, we now show that normal gut and skin γδ IEL development additionally requires Btnl6 and Skint2, respectively, and furthermore that different Btnl ...[more]