An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint.
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ABSTRACT:
SUBMITTER: Ramanan D
PROVIDER: S-EPMC7393667 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint.
Ramanan Deepshika D Sefik Esen E Galván-Peña Silvia S Wu Meng M Yang Liang L Yang Zhen Z Kostic Aleksandar A Golovkina Tatyana V TV Kasper Dennis L DL Mathis Diane D Benoist Christophe C
Cell 20200512 6
At the species level, immunity depends on the selection and transmission of protective components of the immune system. A microbe-induced population of RORγ-expressing regulatory T cells (Tregs) is essential in controlling gut inflammation. We uncovered a non-genetic, non-epigenetic, non-microbial mode of transmission of their homeostatic setpoint. RORγ<sup>+</sup> Treg proportions varied between inbred mouse strains, a trait transmitted by the mother during a tight age window after birth but st ...[more]
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