An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint.

ABSTRACT: At the species level, immunity depends on the selection and transmission of protective components of the immune system. A microbe-induced population of RORγ-expressing regulatory T cells (Tregs) is essential in controlling gut inflammation. We uncovered a non-genetic, non-epigenetic, non-microbial mode of transmission of their homeostatic setpoint. RORγ⁺ Treg proportions varied between inbred mouse strains, a trait transmitted by the mother during a tight age window after birth but stable for life, resistant to many microbial or cellular perturbations, then further transferred by females for multiple generations. RORγ⁺ Treg proportions negatively correlated with IgA production and coating of gut commensals, traits also subject to maternal transmission, in an immunoglo

SUBMITTER: Ramanan D 

PROVIDER: S-EPMC7393667 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature