Dataset Information

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population.

ABSTRACT:

Background

Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon.

Methods

The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn.

Results

None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for MMP-2, MMP-7 and MT2A non-significant differences in genotypes frequencies among cases and controls were observed.

Conclusions

Analyses of polymorphisms, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation.

SUBMITTER: Bialkowska K

PROVIDER: S-EPMC7395404 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Polymorphisms in <i>MMP-1</i>, <i>MMP-2</i>, <i>MMP-7, MMP-13</i> and <i>MT2A</i> do not contribute to breast, lung and colon cancer risk in polish population.

Białkowska Katarzyna K Marciniak Wojciech W Muszyńska Magdalena M Baszuk Piotr P Gupta Satish S Jaworska-Bieniek Katarzyna K Sukiennicki Grzegorz G Durda Katarzyna K Gromowski Tomasz T Lener Marcin M Prajzendanc Karolina K Łukomska Alicja A Cybulski Cezary C Huzarski Tomasz T Gronwald Jacek J Dębniak Tadeusz T Lubiński Jan J Jakubowska Anna A

Hereditary cancer in clinical practice 20200731

<h4>Background</h4>Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon.<h4>Methods</h4>The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 w ...[more]

PMID: 32765800

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