Influence of gastrectomy for gastric cancer treatment on faecal microbiome and metabolome profiles.

ABSTRACT:

Objective

Recent evidence points to the gut microbiome's involvement in postoperative outcomes, including after gastrectomy. Here, we investigated the influence of gastrectomy for gastric cancer on the gut microbiome and metabolome, and how it related to postgastrectomy conditions.

Design

We performed shotgun metagenomics sequencing and capillary electrophoresis time-of-flight mass spectrometry-based metabolomics analyses on faecal samples collected from participants with a history of gastrectomy for gastric cancer (n=50) and compared them with control participants (n=56).

Results

The gut microbiota in the gastrectomy group showed higher species diversity and richness (p<0.05), together with greater abundance of aerobes, facultative anaerobes and oral microbes. Moreov

SUBMITTER: Erawijantari PP 

PROVIDER: S-EPMC7398469 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature