Ischemia considerations for the development of an organ and tissue donor derived bone marrow bank.

ABSTRACT:

Background

Deceased organ donors represent an untapped source of therapeutic bone marrow (BM) that can be recovered in 3-5 times the volume of that obtained from living donors, tested for quality, cryopreserved, and banked indefinitely for future on-demand use. A challenge for a future BM banking system will be to manage the prolonged ischemia times that are inevitable when bones procured at geographically-dispersed locations are shipped to distant facilities for processing. Our objectives were to: (a) quantify, under realistic field conditions, the relationship between ischemia time and the quality of hematopoietic stem and progenitor cells (HSPCs) derived from deceased-donor BM; (b) identify ischemia-time boundaries beyond which HSPC quality is adversely affected; (c) investigate

SUBMITTER: Woods EJ 

PROVIDER: S-EPMC7405448 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature