Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years.

ABSTRACT: Understanding of the role of focal inflammation, a treatable feature, on neuro-axonal injury, is paramount to optimize neuroprotective strategy in MS. To quantify the impact of focal inflammatory activity on the rate of neuro-axonal injury over the MS course. We quantified the annualized rates of change in peripapillary retinal nerve fiber layer, ganglion cell plus inner plexiform layer (GCIPL), whole-brain, gray matter and thalamic volumes in patients with and without focal inflammatory activity in 161 patients followed over 5 years. We used mixed models including focal inflammatory activity (the presence of at least one relapse or a new/enlarging T2-FLAIR or gadolinium- enhancing lesion), and its interaction with time adjusted by age, sex, use of disease-modifying therapies and steroids,

SUBMITTER: Pulido-Valdeolivas I 

PROVIDER: S-EPMC7414206 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature