Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study.
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ABSTRACT: Introduction
Amyloid beta (Aβ) deposition was identified to precede tau pathology and neurodegeneration in familial Alzheimer's disease (AD). But the divergence between sporadic and familial AD limits the extension of these findings to sporadic AD.Methods
Longitudinal changes of biomarkers among different stages were assessed using linear mixed-effects models. The slopes of the models were used to estimate rates of change to calculate the biomarker trajectories in sporadic AD.Results
Cerebrospinal fluid (CSF) Aβ was estimated to decline 45.2 years (abnormal: 27.8 years) before dementia, and Aβ deposition seemed to increase 31.7 years (abnormal: 26.7 years) before dementia. It was estimated to take 29.0 years (CSF t-tau), 12.2 years (memory), 11.6 years (hippocampus), 9.3 years (hypometabolism), and 6.1 years (cognition) to move from normal to dementia.Discussion
The trajectory in sporadic AD is led by Aβ accumulation, followed by CSF t-tau increase, memory deficits, brain atrophy, hypometabolism, and cognitive decline.
SUBMITTER: Wang HF
PROVIDER: S-EPMC7421532 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study.
Wang Hui-Fu HF Shen Xue-Ning XN Li Jie-Qiong JQ Suckling John J Tan Chen-Chen CC Wang Yan-Jiang YJ Feng Lei L Zhang Can C Tan Lan L Dong Qiang Q Touchon Jacques J Gauthier Serge S Yu Jin-Tai JT
Alzheimer's & dementia (Amsterdam, Netherlands) 20200812 1
<h4>Introduction</h4>Amyloid beta (Aβ) deposition was identified to precede tau pathology and neurodegeneration in familial Alzheimer's disease (AD). But the divergence between sporadic and familial AD limits the extension of these findings to sporadic AD.<h4>Methods</h4>Longitudinal changes of biomarkers among different stages were assessed using linear mixed-effects models. The slopes of the models were used to estimate rates of change to calculate the biomarker trajectories in sporadic AD.<h4 ...[more]
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