Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study.

ABSTRACT:

Introduction

Amyloid beta (Aβ) deposition was identified to precede tau pathology and neurodegeneration in familial Alzheimer's disease (AD). But the divergence between sporadic and familial AD limits the extension of these findings to sporadic AD.

Methods

Longitudinal changes of biomarkers among different stages were assessed using linear mixed-effects models. The slopes of the models were used to estimate rates of change to calculate the biomarker trajectories in sporadic AD.

Results

Cerebrospinal fluid (CSF) Aβ was estimated to decline 45.2 years (abnormal: 27.8 years) before dementia, and Aβ deposition seemed to increase 31.7 years (abnormal: 26.7 years) before dementia. It was estimated to take 29.0 years (CSF t-tau), 12.2 years (memory), 11.6 years (hippocampus)

SUBMITTER: Wang HF 

PROVIDER: S-EPMC7421532 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature