Effects of Prior Influenza Exposure on Immunogenicity of Influenza Vaccine.

ABSTRACT:

Background

In this study, we investigated the effects of prior influenza exposure on vaccine-elicited humor immune responses to circulating influenza variants.

Method

We randomly selected 360 participants in previous clinical trials stratified by age. Blood samples were collected and tested by hemagglutination-inhibition tests during the 2015-2016 influenza seasons in China. The antigenic map was plotted and antigenic distance was calculated.

Results

Subjects with H1-priming had higher cross-reactive antibodies titers against A/JiangsuTinghu/11019/2015(H3N2) compared with subjects with B-priming did (P _adjusted = .038). Subjects with H1-priming also had higher cross-reactive antibodies titers against A/Jiangsu Qinhuai/11059/2015(H3N2) than subjects w

SUBMITTER: Cao JQ 

PROVIDER: S-EPMC7423295 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature