Association between tumor necrosis factor alpha and obstructive sleep apnea in adults: a meta-analysis update.

ABSTRACT:

Background

Tumor necrosis factor-α (TNF-α) has been reported to play a part in the development of obstructive sleep apnea (OSA) and its complications. However, the relationship between TNF-α and OSA still remains inconclusive. We aimed to systematically review and synthesize studies published to date on association between the two in adults.

Methods

We searched for English-language articles containing original human data from case-control study studies in adults≥18 years of age. The selection criteria were set according to the PICOS framework. Articles were independently reviewed by three investigators. Data regarding demographics, clinical characteristics, and TNF-α levels were obtained. A random-effects model was applied to evaluate the overall effect sizes by calculating

SUBMITTER: Cao Y 

PROVIDER: S-EPMC7425010 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature