G6PD deficiency in malaria endemic areas of Nepal.

ABSTRACT:

Background

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is currently a threat to malaria elimination due to risk of primaquine-induced haemolysis in G6PD deficient individuals. The World Health Organization (WHO) recommends G6PD screening before providing primaquine as a radical treatment against vivax malaria. However, evidence regarding the prevalence and causing mutations of G6PD deficiency in Nepal is scarce.

Methods

A cross-sectional, population-based, prevalence study was carried out from May to October 2016 in 12 malaria-endemic districts of Nepal. The screening survey included 4067 participants whose G6PD status was determined by G6PD Care Start™ rapid diagnostic test and genotyping.

Results

The prevalence of G6PD deficiency at the national level was 3.

SUBMITTER: Marasini B 

PROVIDER: S-EPMC7425560 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature