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Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research.
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ABSTRACT: Introduction
Despite significant advances in treatment and prevention of HIV-1 infection, poor adherence to daily combination antiretroviral therapy (ART) regimens remains a major obstacle toward achieving sustained viral suppression and prevention. Adherence to ART could also be compromised by adverse drug reactions and societal factors that limit access to therapy. Therefore, medicines that aim to improve adherence by limiting ART side effects, frequency of dosing and socially acceptable regimens are becoming more attractive.Areas covered
This review highlights recent advances and challenges in the development of long-acting drug delivery strategies for HIV prevention and treatment. Approaches for extended oral and transdermal deliveries, microbicides, broadly neutralizing antibodies, and long-acting implantable and injectable deliveries are reviewed.Expert opinion
Emerging approaches on long-acting antiretroviral therapies and broadly neutralizing antibody technologies are currently at various stages of development. Such efforts, if successful and become broadly accepted by clinicians and users, will provide newer and simpler options for prevention and treatment of HIV infection.
SUBMITTER: Cobb DA
PROVIDER: S-EPMC7442675 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research.
Expert opinion on drug delivery 20200706 9
<h4>Introduction</h4>Despite significant advances in treatment and prevention of HIV-1 infection, poor adherence to daily combination antiretroviral therapy (ART) regimens remains a major obstacle toward achieving sustained viral suppression and prevention. Adherence to ART could also be compromised by adverse drug reactions and societal factors that limit access to therapy. Therefore, medicines that aim to improve adherence by limiting ART side effects, frequency of dosing and socially acceptab ...[more]