Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research.

ABSTRACT:

Introduction

Despite significant advances in treatment and prevention of HIV-1 infection, poor adherence to daily combination antiretroviral therapy (ART) regimens remains a major obstacle toward achieving sustained viral suppression and prevention. Adherence to ART could also be compromised by adverse drug reactions and societal factors that limit access to therapy. Therefore, medicines that aim to improve adherence by limiting ART side effects, frequency of dosing and socially acceptable regimens are becoming more attractive.

Areas covered

This review highlights recent advances and challenges in the development of long-acting drug delivery strategies for HIV prevention and treatment. Approaches for extended oral and transdermal deliveries, microbicides, broadly neutralizin

SUBMITTER: Cobb DA 

PROVIDER: S-EPMC7442675 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature