Features of alternative splicing in stomach adenocarcinoma and their clinical implication: a research based on massive sequencing data.

ABSTRACT:

Background

Alternative splicing (AS) offers a main mechanism to form protein polymorphism. A growing body of evidence indicates the correlation between splicing disorders and carcinoma. Nevertheless, an overall analysis of AS signatures in stomach adenocarcinoma (STAD) is absent and urgently needed.

Results

2042 splicing events were confirmed as prognostic molecular events. Furthermore, the final prognostic signature constructed by 10 AS events gave good result with an area under the curve (AUC) of receiver operating characteristic (ROC) curve up to 0.902 for 5 years, showing high potency in predicting patient outcome. We built the splicing regulatory network to show the internal regulation mechanism of splicing events in STAD. QKI may play a significant part in the prognosi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7443856 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature