Extracapsular extension on MRI indicates a more aggressive cell cycle progression genotype of prostate cancer.

ABSTRACT:

Purpose

To explore associations between magnetic resonance imaging (MRI) features of prostate cancer and expression levels of cell cycle genes, as assessed by the Prolaris^® test.

Materials and methods

Retrospective analysis of 118 PCa patients with genetic testing of biopsy specimen and prostate MRI from 08/2013 to 11/2015. Associations between the cell cycle risk (CCR) score and MRI features [i.e., PI-RADSv2 score, extracapsular extension (ECE), quantitative metrics] were analyzed with Fisher's exact test, nonparametric tests, and Spearman's correlation coefficient. In 41 patients (34.7%), test results were compared to unfavorable features on prostatectomy specimen (i.e., Gleason group ≥ 3, ECE, lymph node metastases).

Results

Fifty-four (45.8%), 60 (50.8%

SUBMITTER: Wibmer AG 

PROVIDER: S-EPMC7446140 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature