Design and evaluation of collagen-inspired mineral-hydrogel nanocomposites for bone regeneration.

ABSTRACT: Bone loss due to trauma and tumors remains a serious clinical concern. Due to limited availability and disease transmission risk with autografts and allografts, calcium phosphate bone fillers and growth factor-based substitute bone grafts are currently used in the clinic. However, substitute grafts lack bone regeneration potential when used without growth factors. When used along with the added growth factors, they lead to unwanted side effects such as uncontrolled bone growth. Collagen-based hydrogel grafts available on the market fail to provide structural guidance to native cells due to high water-solubility and faster degradation. To overcome these limitations, we employed bioinspired material design and fabricated three different hydrogels with structural features similar to native co

SUBMITTER: Patel A 

PROVIDER: S-EPMC7446305 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature