Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients.

ABSTRACT:

Background

During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients.

Methods

The IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections.

Results

We describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association with either neurologic or thrombotic complications. In sequential pre- and post-COVID-19 serum samples, we confirmed autoAb seroconversion.

Conclusions

Our data indicate that autoAb screening in COVID-19 patients may be easily performed by IF and alert for autoreactive-mediated complications su

SUBMITTER: Schiaffino MT 

PROVIDER: S-EPMC7454719 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature