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Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients.

ABSTRACT:

Background

During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients.

Methods

The IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections.

Results

We describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association with either neurologic or thrombotic complications. In sequential pre- and post-COVID-19 serum samples, we confirmed autoAb seroconversion.

Conclusions

Our data indicate that autoAb screening in COVID-19 patients may be easily performed by IF and alert for autoreactive-mediated complications such as thrombotic or neurologic events.

SUBMITTER: Schiaffino MT

PROVIDER: S-EPMC7454719 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients.

Schiaffino María Teresa MT Di Natale Marisa M García-Martínez Elena E Navarro Joaquín J Muñoz-Blanco José Luis JL Demelo-Rodríguez Pablo P Sánchez-Mateos Paloma P

The Journal of infectious diseases 20201001 9

<h4>Background</h4>During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients.<h4>Methods</h4>The IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections.<h4>Results</h4>We describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association wi ...[more]

PMID: 32738141

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