Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC7458867 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Science immunology 20190601 36
CD8<sup>+</sup> tissue-resident memory T (T<sub>RM</sub>) cells provide frontline immunity in mucosal tissues. The mechanisms regulating CD8<sup>+</sup> T<sub>RM</sub> maintenance, heterogeneity, and protective and pathological functions are largely elusive. Here, we identify a population of CD8<sup>+</sup> T<sub>RM</sub> cells that is maintained by major histocompatibility complex class I (MHC-I) signaling, and CD80 and CD86 costimulation after acute influenza infection. These T<sub>RM</sub> ce ...[more]