PD-1^hi CD8⁺ resident memory T cells balance immunity and fibrotic sequelae.

ABSTRACT: CD8⁺ tissue-resident memory T (T_RM) cells provide frontline immunity in mucosal tissues. The mechanisms regulating CD8⁺ T_RM maintenance, heterogeneity, and protective and pathological functions are largely elusive. Here, we identify a population of CD8⁺ T_RM cells that is maintained by major histocompatibility complex class I (MHC-I) signaling, and CD80 and CD86 costimulation after acute influenza infection. These T_RM cells have both exhausted-like phenotypes and memory features and provide heterologous immunity against secondary infection. PD-L1 blockade after the resolution of primary infection promotes the rejuvenation of these exhausted-like T_RM cells, restoring protective immunity at the cost of pro

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7458867 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature