Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent.

ABSTRACT: Infection of the central nervous system (CNS) by murine polyomavirus (MuPyV), a persistent natural mouse pathogen, establishes brain-resident memory CD8 T cells (bT_RM) that uniformly and chronically express programmed cell death protein 1 (PD-1) irrespective of the expression of α_E integrin CD103, a T_RM cell marker. In contrast, memory antiviral CD8 T cells in the spleen are PD-1^-, despite viral loads being similar in both the brain and spleen during persistent infection. Repetitive antigen engagement is central to sustained PD-1 expression by T cells in chronic viral infections; however, recent evidence indicates that expression of inhibitory receptors, including PD-1, is part of the T_RM differentiation program. Here we asked whether

SUBMITTER: Shwetank 

PROVIDER: S-EPMC5698165 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature