What If the Influenza Vaccine Did Not Offer Such Variable Protection?

ABSTRACT:

Background

The protection that an influenza vaccine offers can vary significantly from person to person due to differences in immune systems, body types, and other factors. The question, then, is what is the value of efforts to reduce this variability such as making vaccines more personalized and tailored to individuals.

Methods

We developed a compartment model of the United States to simulate different influenza seasons and the impact of reducing the variability in responses to the influenza vaccine across the population.

Results

Going from a vaccine that varied in efficacy (0-30%) to one that had a uniform 30% efficacy for everyone averted 16.0-31.2 million cases, $1.9-$3.6 billion in direct medical costs, and $16.1-$42.7 billion in productivity losses. Going from 0

SUBMITTER: Bartsch SM 

PROVIDER: S-EPMC7459138 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature