Immunomodulatory Effects of N-Acetyl Chitooligosaccharides on RAW264.7 Macrophages.

ABSTRACT: The ongoing development of new production methods may lead to the commercialization of N-acetyl chitooligosaccharides (NACOS), such as chitosan oligosaccharides (COS). The bioactivity of NACOS, although not well detailed, differs from that of COS, as they have more acetyl groups than COS. We used two enzymatically produced NACOS with different molecular compositions and six NACOS (NACOS1-6) with a single degree of polymerization to verify their immunomodulatory effects on the RAW264.7 macrophage cell line. We aimed to identify any differences between COS and various NACOS with a single degree of polymerization. The results showed that NACOS had similar immune enhancement effects on RAW264.7 cells as COS, including the generation of reactive oxygen species (ROS), phagocytotic activit

SUBMITTER: Deng JJ 

PROVIDER: S-EPMC7460392 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature