Ontology highlight
ABSTRACT:
SUBMITTER: Dennis ML
PROVIDER: S-EPMC7466750 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Acta crystallographica. Section D, Structural biology 20200817 Pt 9
Cancer is one of the leading causes of mortality in humans, and recent work has focused on the area of immuno-oncology, in which the immune system is used to specifically target cancerous cells. Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is an emerging therapeutic target in human cancers owing to its role in degrading cyclic GMP-AMP (cGAMP), an agonist of the stimulator of interferon genes (STING). The available structures of ENPP1 are of the mouse enzyme, and no structures are a ...[more]