Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure.

ABSTRACT:

Background

Elevated surfactant protein D (SP-D) is a relatively specific indicator of lung injury and is associated with both acute and chronic lung disease in adults and respiratory distress syndrome in premature infants. The relationship between plasma SP-D and lung injury in children with acute respiratory failure is unclear.

Research question

Is plasma SP-D associated with lung injury or outcome in children with acute respiratory failure?

Study design and methods

This was a prospective cohort study in children 2 weeks to 17 years of age with acute respiratory failure who participated in the BALI multi-center study. Analyses were done using SP-D levels in plasma from the first sample taken on either the day of intubation or one of the following 2 days. SP-D level w

SUBMITTER: Dahmer MK 

PROVIDER: S-EPMC7478231 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature