Amalgamated cross-species transcriptomes reveal organ-specific propensity in gene expression evolution.
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ABSTRACT:
SUBMITTER: Fukushima K
PROVIDER: S-EPMC7479108 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Amalgamated cross-species transcriptomes reveal organ-specific propensity in gene expression evolution.
Fukushima Kenji K Pollock David D DD
Nature communications 20200908 1
The origins of multicellular physiology are tied to evolution of gene expression. Genes can shift expression as organisms evolve, but how ancestral expression influences altered descendant expression is not well understood. To examine this, we amalgamate 1,903 RNA-seq datasets from 182 research projects, including 6 organs in 21 vertebrate species. Quality control eliminates project-specific biases, and expression shifts are reconstructed using gene-family-wise phylogenetic Ornstein-Uhlenbeck mo ...[more]
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