Amalgamated cross-species transcriptomes reveal organ-specific propensity in gene expression evolution.

ABSTRACT: The origins of multicellular physiology are tied to evolution of gene expression. Genes can shift expression as organisms evolve, but how ancestral expression influences altered descendant expression is not well understood. To examine this, we amalgamate 1,903 RNA-seq datasets from 182 research projects, including 6 organs in 21 vertebrate species. Quality control eliminates project-specific biases, and expression shifts are reconstructed using gene-family-wise phylogenetic Ornstein-Uhlenbeck models. Expression shifts following gene duplication result in more drastic changes in expression properties than shifts without gene duplication. The expression properties are tightly coupled with protein evolutionary rate, depending on whether and how gene duplication occurred. Fluxes in expression

SUBMITTER: Fukushima K 

PROVIDER: S-EPMC7479108 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature