Interferon gamma gene polymorphisms and chronic hepatitis B infections in an Iranian population.

ABSTRACT:

Background and aims

Chronic hepatitis B is an important health problem in all countries. I Interferon gamma is a pro-inflammatory Th1 cytokines, which can exert antiproliferative and antitumor activity. Some SNPs in IFN-γ and IFN-γR1 genes may influence the susceptibility to HBV. Here, we evaluated the impact of interferon gamma (+874 T/A) and its receptor (-611A/G, +189G/C and +95C/T) polymorphisms and the risk of HBV in Iranian patients.

Materials and methods

SNPs of interferon gamma and its receptor genotypes were determined in 221 infected patients with HBV and 200 people without HBV using ARMS-PCR and PCR- RFLP method.

Results

In this study, we showed an obvious relationship between IFN-γ SNPs and susceptibility to chronic HBV. Our findings suggest that IFN-γ-874

SUBMITTER: Heidari Z 

PROVIDER: S-EPMC7480198 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature