Salivary microRNAs show potential as biomarkers for early diagnosis of malignant pleural effusion.

ABSTRACT:

Background

Malignant pleural effusion (MPE) is a common medical problem caused by multiple malignancies, especially lung cancers, and always comes along with a poor outcome. Early detection and diagnosis are important for improving the prognosis in patients with MPE. Salivary microRNAs (miRNAs) may represent a relatively convenient way for diagnosing MPE. We investigated the characteristics of salivary miRNAs of MPE patients, benign pleural effusion (BPE) patients, patients with a malignant tumor but without pleural effusion (MT), and healthy controls (HCs). We believe that they may show potential as a non-invasive and convenient biomarker for diagnosing MPE.

Methods

From January 1, 2019, to July 1, 2019, 57 MPE patients, 33 BPE patients, 50 MT patients, and 49 HCs were enro

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7481620 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature