The Effect of the APOE ε2ε4 Genotype on the Development of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) in Non-Latino Whites.

ABSTRACT:

Objectives

To examine the associations of APOE ε2ε4 with the development of Alzheimer's disease (AD) and mild cognitive impairment (MCI) in non-Latino whites.

Design

Prospective longitudinal cohort study.

Setting

Uniform Data Set from the National Alzheimer's Coordinating Center (NACC) between 2005 and August 2018 (data freeze in September 2018).

Participants

Participants who were non-Latino white, had an APOE genotype available, first visit with dementia free for AD cohort and both dementia and MCI free for MCI cohort, and had a minimum of one follow-up visit (n = 11 871 for AD cohort, and n = 8305 for MCI cohort).

Measurements

The incidences of AD and MCI were determined based on consensus meetings at each Alzheimer's disease center. We used NACC-deriv

SUBMITTER: Ren D 

PROVIDER: S-EPMC7482099 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature