Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer? A cross-sectional study in Japan.

ABSTRACT:

Objective

To investigate whether smoking duration alone can replace pack-years to predict the risk of oncogenic mutations in non-small cell lung cancer (NSCLC).

Design

A cross-sectional study using the baseline dataset from the Japan Molecular Epidemiology for Lung Cancer Study.

Setting

Forty-three medical institutions nationwide in Japan.

Participants

From July 2012 to December 2013, 957 patients with newly diagnosed stage I-IIIB NSCLC who underwent surgery were enrolled, and molecular analyses were performed on 876 samples (from 441 ever-smokers and 435 never-smokers).

Main outcomes measured

We calculated the area under the receiver operating characteristic curve (AUC) values using logistic regression to compare between the predictive values of smoking

SUBMITTER: Ogawa K 

PROVIDER: S-EPMC7482473 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature