Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC7486546 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Asian journal of pharmaceutical sciences 20190705 4
The therapeutic efficiency of active targeting nanoparticulate drug delivery systems (nano-DDS) is highly compromised by the plasma proteins adsorption on nanoparticles (NPs) surface, which significantly hinders cell membrane receptors to recognize the designed ligands, and provokes the off-target toxicity and rapid clearance of NPs <i>in vivo</i>. Herein, we report a novel dihydroartemisinin (DHA)-decorating nano-DDS that <i>in situ</i> specifically recruits endogenous apolipoprotein E (apoE) o ...[more]