Longitudinal functional connectivity changes related to dopaminergic decline in Parkinson's disease.

ABSTRACT:

Background

Resting-state functional magnetic resonance imaging (fMRI) studies have demonstrated that basal ganglia functional connectivity is altered in Parkinson's disease (PD) as compared to healthy controls. However, such functional connectivity alterations have not been related to the dopaminergic deficits that occurs in PD over time.

Objectives

To examine whether functional connectivity impairments are correlated with dopaminergic deficits across basal ganglia subdivisions in patients with PD both cross-sectionally and longitudinally.

Methods

We assessed resting-state functional connectivity of basal ganglia subdivisions and dopamine transporter density using ¹¹C-PE2I PET in thirty-four PD patients at baseline. Of these, twenty PD patients were rescann

SUBMITTER: Li W 

PROVIDER: S-EPMC7490914 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature