Ontology highlight
ABSTRACT:
SUBMITTER: Song E
PROVIDER: S-EPMC7491522 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Song Eric E Zhang Ce C Israelow Benjamin B Lu-Culligan Alice A Prado Alba Vieites AV Skriabine Sophie S Lu Peiwen P Weizman Orr-El OE Liu Feimei F Dai Yile Y Szigeti-Buck Klara K Yasumoto Yuki Y Wang Guilin G Castaldi Christopher C Heltke Jaime J Ng Evelyn E Wheeler John J Alfajaro Mia Madel MM Levavasseur Etienne E Fontes Benjamin B Ravindra Neal G NG Van Dijk David D Mane Shrikant S Gunel Murat M Ring Aaron A Kazmi Syed A Jaffar SAJ Zhang Kai K Wilen Craig B CB Horvath Tamas L TL Plu Isabelle I Haik Stephane S Thomas Jean-Leon JL Louvi Angeliki A Farhadian Shelli F SF Huttner Anita A Seilhean Danielle D Renier Nicolas N Bilguvar Kaya K Iwasaki Akiko A
bioRxiv : the preprint server for biology 20200908
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there is no consensus whether the virus can infect the brain, or what the consequences of CNS infection are. Here, we used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. First, using human brain organoids, we observed clear evidence of infection with accompanying metabolic changes in the infected a ...[more]