Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies.

ABSTRACT: BACKGROUND:Members of the melanoma-associated antigen-A (MAGE-A) subfamily are overexpressed in many cancers and can drive cancer progression, metastasis, and therapeutic recurrence. OBJECTIVE:This study is the first comprehensive meta-analysis evaluating the prognostic utility of MAGE-A members in different cancers. METHODS:A systematic literature search was conducted in PubMed, Google Scholar, Science Direct, and Web of Science. The pooled hazard ratios with 95% confidence intervals were estimated to evaluate the prognostic significance of MAGE-A expression in various cancers. RESULTS:In total, 44 eligible studies consisting of 7428 patients from 11 countries were analysed. Univariate and multivariate analysis for overall survival, progression-free survival, and disease-free survival showed a significant association between high MAGE-A expression and various cancers (P?

SUBMITTER: Poojary M 

PROVIDER: S-EPMC7497308 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature