Molecular genotypes of gag sequences in HIV-1 infected children treated with antiretroviral therapy in Vietnam.

ABSTRACT:

Background

Gag protein of human immunodeficiency virus (HIV) has been reported to play a crucial role in establishing infection, viral replication, and disease progression; thus, gag might be related to treatment response. The objective of this study was to investigate molecular genotypes of the gag gene, particularly the important functional binding domains in relation to treatment outcomes.

Methods

HIV-infected children enrolled and treated at Vietnam National Children's Hospital were recruited in the study. A total of 25 gag sequences were generated and used to construct phylogenetic trees and aligned with a reference sequence comparing 17 functional domains.

Results

We found that all patients in a treatment failure (TF) group belonged to one cluster of the phyloge

SUBMITTER: Dang LVP 

PROVIDER: S-EPMC7502858 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature