Analysis of long noncoding RNA-associated competing endogenous RNA network in glucagon-like peptide-1 receptor agonist-mediated protection in β cells.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) and mRNAs are widely involved in various physiological and pathological processes. The use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) is a novel therapeutic strategy that could promote insulin secretion and decrease the rate of β-cell apoptosis in type 2 diabetes mellitus (T2DM) patients. However, the specific lncRNAs and mRNAs and their functions in these processes have not been fully identified and elucidated.

Aim

To identify the lncRNAs and mRNAs that are involved in the protective effect of GLP-1RA in β cells, and their roles.

Methods

Rat gene microarray was used to screen differentially expressed (DE) lncRNAs and mRNAs in β cells treated with geniposide, a GLP-1RA. Gene Ontology (GO) and Kyoto Encyclopedia of

SUBMITTER: Cui LJ 

PROVIDER: S-EPMC7503504 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature