Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques.

ABSTRACT: Social experience is an important predictor of disease susceptibility and survival in humans and other social mammals. Chronic social stress is thought to generate a proinflammatory state characterized by elevated antibacterial defenses and reduced investment in antiviral defense. Here we manipulated long-term social status in female rhesus macaques to show that social subordination alters the gene expression response to ex vivo bacterial and viral challenge. As predicted by current models, bacterial lipopolysaccharide polarizes the immune response such that low status corresponds to higher expression of genes in NF-κB-dependent proinflammatory pathways and lower expression of genes involved in the antiviral response and type I IFN signaling. Counter to predictions, however, low status dri

SUBMITTER: Sanz J 

PROVIDER: S-EPMC7519294 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature