Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients.

ABSTRACT: Acute lymphocytic leukemia (ALL) is one of the most common malignancies, especially in young people. Combination chemotherapy for ALL typically includes corticosteroids (Kantarjian et al., 2000). Hyperglycemia is a well-recognized complication of corticosteroids, and chemotherapy-induced diabetes (CID) is not uncommon (27.5%-37.0%) during the treatment of ALL (Hsu et al., 2002; Weiser et al., 2004; Alves et al., 2007). Besides the effect of corticosteroids, potential factors triggering hyperglycemia in ALL also include direct infiltration of the pancreas by leukemia cells and β cell dysfunction induced by chemotherapeutic agents such as L-asparagine (Mohn et al., 2004).

SUBMITTER: Suo SS 

PROVIDER: S-EPMC7519633 | biostudies-literature | 2020 Sept.

REPOSITORIES: biostudies-literature