Salivary microbiome in patients undergoing hemodialysis and its associations with the duration of the dialysis.

ABSTRACT:

Background

Chronic kidney disease (CKD) patients, especially those with end stage renal disease (ESRD) undergoing hemodialysis (HD), exhibit high prevalence of periodontitis. This cross-sectional study aimed to investigate the periodontal status of HD patients and its relationship with salivary microbiome.

Methods

One hundred eight HD patients and one hundred healthy control individuals were recruited. They were subjected to periodontal examination followed by saliva samples collection for 16S rRNA gene sequencing.

Results

The HD patients were with worse periodontal health status, and exhibited higher salivary microbial diversity and lower richness. The periodontal pathogens were significantly enriched in the HD patients. The inferred functional analyze showed microbe

SUBMITTER: Duan X 

PROVIDER: S-EPMC7523083 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature