Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma.

ABSTRACT:

Objective

The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS).

Methods

This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I-IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma; n = 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma; n = 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome.

Results

Tumors in the LVSI-

SUBMITTER: Matsuo K 

PROVIDER: S-EPMC7523233 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature